The Insigneo Institute is dedicated to realise the vision of in silico medicine. To achieve this, Insigneo members require access to diverse software solutions and online services to support their research. The nature of this software covers a broad range, including many programming languages and encompassing commercial, open source and in-house software.

The main function of our software workgroup is to provide a focus for the development of, and support for, Insigneo software tools. This includes negotiating with commercial entities to improve license agreements and the development and maintenance of specialised software.

The workgroup actively promotes the use and development of in house software and projects developed under the umbrella of the Insigneo Institute (including MAF applications, VPH-Share technologies, VPH-HF). It also provides advice and support for grant applications that require new software development.

Online services available through Insigneo include:

CT2S Service – non invasive bone strength estimation

The CT2S service provides an estimate of the strength of human bone, using non-invasive medical imaging.

A patient-specific finite element model of the bone is created, using a state of the art image-processing pipeline. This very precise model of the patient’s anatomy is then examined under a range of highly realistic simulated loading conditions, including walking, running, stair-climbing and falling, and the fracture load is computed in each case.

For more information visit:

XCT2FE – generates microFE models from HRpQCT digital medical imaging

This is the main code in which DICOM (Digital Imaging and Communications in Medicine) images are read and several functions are called in order to generate the microFE (microstructural Finite Element) model.

The service can:

  • Import DICOM images
  • Separate main radius from surrounding bone
  • Separate Cortical from trabecular bone
  • Calculation of morphological parameters. This will serve as inputs for the next step

For more information visit:

Finally, this workgroup encourages training activities to promote best coding practice to ensure software sustainability and training for the use of both in house and commercial software in collaboration with other workgroups.

For more information please contact Will Furnass.