Pathophysiology of ageing

A significant number of cardiovascular, respiratory, musculoskeletal, neurological, and/or oncological diseases manifest mostly among the elderly. Specific clinical problems (gerontology) not withstanding, there is fundamental research territory that relates to the biology of ageing, the comorbidities observed in elderly patients, and the potential opportunity of discovering underlying common mechanisms among pathologies related to the ageing process, which if targeted might actually more effectively address the general condition of the patient, than the simple accumulation of single-disease therapies.

From the development of murine models for the pathophysiology of ageing, to the study of chromosome integrity in the ageing body, to the phenotype characterisation of ageing in the neuromotor, musculoskeletal, cardiovascular, and respiratory systems, there is fundamental role for Predictive Medicine in dealing with the inherent complexity that the pathophysiology of ageing implies. For example in a recent BBSRC funded project, we are investigating the effect of geroprotectors (age-delaying treatments) on the musculoskeletal health in a murine model.

PIs: Prof Ilaria Bellantuono, Oncology and Metabolism; Dr Enrico Dall’Ara, Oncology and Metabolism; Prof Eugene McCloskey, Oncology and Metabolism; Prof Carl Smythe, Biomedical Science; Prof Sheila Francis, Infection, Immunity & Cardiovascular Disease; Dr Tim Chico, Infection, Immunity & Cardiovascular Disease.