Our Research

The Insigneo Institute for in silico Medicine supports the development of patient centred healthcare systems in order to provide clinicians with the tools to interpret medical data in new ways. These new technologies support the work of clinicians, giving them a broader and deeper insight into the underlying physiological problems of an individual patient.

The developed technologies are based on mechanistic or phenomenological models, which can accurately predict the evolution of a condition or the effect of an intervention. Such an informed patient centred healthcare approach will drastically improve the prevention, diagnosis, treatment and monitoring of many diseases.

In addition to modeller experts, the Insigneo Institute for in silico Medicine has adopted an integrative approach by including experimentalists within the Institute to be able to generate knowledge from either in vitro biological processes or from patient measurements (such as clinical imaging, wearable sensors, medical informatics) so that the data can either inform the models and be used as input data or validation tools.

Insigneo Research in figures:

The unique collaboration between academics from the University of Sheffield and clinicians and clinical researchers from the Sheffield Teaching Hospitals NHS Foundation Trust, provides an exceptional mix of insights and resources which further the advancement of in silico research here in Sheffield, with a vision to provide better healthcare for the future. Clinical translation is at the heart of Insigneo’s vision and the collaboration between clinicians and researchers enables us to achieve this goal.

There are two main pillars of research within the Insigneo Institute which are supported by horizontal fundamental biomedical research programmes:

Main pillars of research:

Cardiovascular, respiratory, and urinary pathologies
Neuromotor, musculoskeletal, metabolic, and oncological pathologies

Horizontal fundamental biomedical research programmes:

Mechanobiology of connective tissues
Reduction, refinement and replacement of animal experimentation
Computational neuroscience and neuroimaging
Pathophysiology of ageing

We will continue to update these pages with the latest developments, so please check back or sign up to the Insigneo newsletter to read about the latest developments here at the Institute.