Mechanobiology of connective tissues

Some connective tissues (vascular, hyaline cartilage, bone, ligaments and tendons, skin, etc) are particularly sensitive to mechanical stimuli, and quite a lot of their physiological and pathological behaviours involve some sort of mechanoregulation. However, this is an area historically neglected by more chemistry-oriented biology, so very little is known about many essential mechanisms.

Using in vitro and in vivo experimentation, imaging, sensing, and modelling, we are advancing considerably in the investigation of the effect of mechanical stimuli on tissues and cells.

PIs: Prof Paul Evans, Cardiovascular Science; Prof Damien Lacroix, Mechanical Engineering; Prof Sheila McNeil, Materials Science and Engineering; Dr Enrico Dall’Ara, Oncology and Metabolism; Dr. Gwen Reilly, Materials Science and Engineering; Dr. Paul Watton, Computer Science.