Our clinical champions – meet the clinical champions of in silico medicine

Insigneo is the largest research institute in Europe entirely dedicated to in silico Medicine, and it includes among its ranks some of the most respected specialists in the world. Here are a few of our many clinical champions; learn more about the work they have been doing and read what they have to say about working with Insigneo.


Professor Julian Gunn
Professor of Interventional Cardiology
Honorary Consultant Cardiologist,
Northern General Hospital

Profile: https://www.sheffield.ac.uk/iicd/profiles/gunn



“Insigneo offers clinicians a chance to interact with mathematicians, engineers and computational modellers who are keen to bring their skills to bear on clinical problems. This is really what ‘in silico medicine’ means to me. Research questions can be raised, and solutions sought through computational modelling from the sort of data that we collect every day in our clinical practice. There is a great strength in this area in Sheffield, and Insigneo has brought  everyone together. There are workgroups in major areas (mine is cardio-respiratory) which have regular meetings – please come – and contacts can be made through the chairman with experts who can help. It is surprising how often that techniques used in one area are applicable to another. Contact me or anyone on this website for more details. We would be pleased to hear from you.”


Professor Richard Eastell
Professor of Bone Metabolism
Honorary Consultant Physician in Metabolic bone disease, Northern General Hospital

Profile: https://www.sheffield.ac.uk/oncology-metabolism/staff/eastell


“I have been working with Insigneo for almost 7 years and this has resulted in joint publications between Insigneo and the Mellanby Centre on the topic of finite element modelling of the femur for fracture risk prediction. We have ongoing grants with Insigneo to better understand muscle function and bone strength in elderly people who fall. Finally, we have joint PhD studentships with Insigneo.

The application of engineering models to bone health has proven very fruitful as have the links between Insigneo and the Mellanby Centre for Bone Research.”


Dr Alasdair McNeill
Insigneo Senior Clinical Research Fellow
Honorary Consultant in Clinical Genetics,
Sheffield Childrens Hospital

Profile: https://www.sheffield.ac.uk/neuroscience/staff/mcneill


“I have been funded by an Insigneo senior clinical research fellowship since 2015. I work with Dr Claudia Mazzà on applying human movement analysis techniques to neurological disorders. We are using these techniques as potential biomarkers of disease progression in people with genetic ataxia and who carry mutations in ataxia genes but who do not yet have a movement disorder. In collaboration with Professor Bandmann (Sheffield Teaching Hospital Neurosciences) we are using these techniques as a potential biomarker for a drug trial in Parkinsons disease. Lastly, we are using human movement analysis techniques to study a cohort of patients at high genetic risk of Parkinson’s disease (22q11 deletion syndrome) for evidence of early motor dysfunction to enable early diagnosis of a movement disorder. These techniques enable us to gather vital information on a patient’s neurological status which would not be possible through bedside clinical examination alone.”


Professor David Kiely

Consultant Respiratory Physician
Honorary Professor of Pulmonary Vascular Medicine

Profile: https://www.sheffield.ac.uk/iicd/profiles/kiely


Dr Amaka Offiah

Reader in Paediatric Musculoskeletal imaging, Sheffield Childrens Hospital NHS Foundation Trust

Profile: https://www.sheffield.ac.uk/oncology-metabolism/staff/offiah




“I’m involved with Insigneo in relation to developing finite element models of children’s bones to better understand injury mechanisms in general and in the context of suspected child abuse in particular. This collaboration is important, as there is no other way to objectively study injury mechanisms in children below the age of 2 years (the age at which inflicted injury most commonly occurs in children).

The collaboration has already led to a number of publications, including significant media interest e.g.

Investigating the mechanical response of paediatric bone under bending and torsion using finite element analysis (J Biomec Mod Mechanobiol) Aug 2018 Altai Z, Viceconti M, Offiah AC, Li X ;17:1001-1009 doi: 10.1007/s10237-018-1008-9

Developing CT based computational models of pediatric femurs (J Biomech) Jul 2015 Li X, Viceconti M, Cohen MC, Reilly G, Carre MJ, Offiah AC