- About Insigneo
- In Silico Medicine: Definition, History, Institutions, Main Achievements
- The Insigneo Institute: Vision, Mission, Values, History, Organisation
- Insigneo Board Members
Professor Claudia Mazzà – Interim Executive Director
Professor Claudia Mazzà is the Interim Executive Director at the Insigneo Institute for in silico Medicine and course director for the MSc Computational Medicine. Claudia has been an integral member of the Insigneo Institute since her arrival in Sheffield.
Claudia received her PhD in Bioengineering in 2004 from the University of Bologna. She carried out her PhD and post-doc related research activities at the Department of Human Movement Sciences at the University of Rome “Foro Italico”, where she was appointed as Assistant Professor from Jan 2006 to Jan 2013. She joined the University of Sheffield as a lecturer in Feb 2013 and became Reader in Biomechanics in January 2017 and Professor in 2019.
Claudia’s research focuses on the biomechanics of human movement and on the definition of quantative methods for the clinical assessment of an individual locomotor and postural ability. She has extensive experience with large collaborative EU projects, as a Co-I in Md-Paedigree (Model-Driven Paediatric European Digital Repository) and as a WP leader in MissionT2D (Multiscale Immune System Simulator for the Onset of Type 2 Diabetes integrating genetic, metabolic and nutritional data) and in the H2020 Marie Skłodowska-Curie Innovative Training Network SPINNER (SPINe: Numerical and Experimental Repair strategies) aimed at improving biomaterials and surgical interventions for treatments of debilitating spine disorder. She is currently leading the EPSRC Frontier Engineering Award, MultiSim and the in silico medicine theme in the NIHR Sheffield Biomedical Research Centre (BRC) in Translational Neuroscience, where she is translating the work done within MultiSim to the investigation of Neurodegenerative disease.
Professor Jim Wild – Director of Research
Professor Jim Wild is a Magnetic Resonance Physicist who joined the University of Sheffield in 2000 to set up the technology for hyperpolarised gas lung Magnetic Resonance Imaging (MRI).
Jim’s research focuses on the physics and engineering and clinical applications of hyperpolarised gas (3He and 129Xe) and proton MRI in the lungs and pulmonary vasculature.
His research has demonstrated the role of these pulmonary MRI methods in Asthma, COPD, Cystic Fibrosis, Interstitial Lung Disease, Lung cancer and Pulmonary Hypertension. Using hyperpolarised gas and proton lung MRI he is evaluating novel pulmonary therapies in collaboration with pharmaceutical companies. The lung imaging methods and models are the basis of patient specific in silico models of lung disease at Insigneo in VPH projects such as Airprom.
His POLARIS research group are based in Academic Radiology in the Medical School which is home to the Insigneo image computing lab.
Dr Andrew Narracott – Director of Operations
Dr Andrew Narracott is a Senior Lecturer in Cardiovascular Mechanics in the Department of Infection, Immunity and Cardiovascular Disease. He completed a Masters degree in Physics in 1997 and has a PhD in computational and experimental characterisation of coronary stent deployment from the University of Sheffield in 2002.
Andrew’s research experience in EC and international research projects includes a six month research fellowship at the RIKEN Institute, Tokyo, Japan. He has worked closely with industry, including consultancy for Huntleigh Healthcare. Research topics have included a clinical decision support system for haemodialysis patients within the FP7 ARCH project and strategies for training through research within the FP7 MeDDiCA and H2020 VPH-CaSE Marie Curie European Training Networks. He represents the University of Sheffield on the VPH Institute Board
Andrew’s research interests include simulation and experimental measurement of the cardiovascular system, with focus on the role of the venous circulation in health and disease.
Dr Gwendolen Reilly – Director of Training
Dr Gwendolen Reilly is a Reader in Bioengineering, Department of Materials Science and Engineering and the Faculty of Engineering Director of Equality, Diversity and Inclusion. She has been a member of academic staff at the University of Sheffield since 2004. She received her DPhil in Biology at the University of York, specializing in bone biomechanics. Since then she has conducted research in the fields of bone mechanobiology and then biomaterials and tissue engineering in institutions in Switzerland (ETH) and the US (Penn State, U. Penn and UIChicago).
Gwen’s research centres around two key themes; the effects of mechanical stimulation on differentiation and matrix formation by bone cells and the interactions between precursor bone cells and their biomaterial substrates. She is PI on the H2020 Marie Skłodowska-Curie Innovative Training Network SPINNER (SPINe: Numerical and Experimental Repair strategies) aimed at improving biomaterials and surgical interventions for treatments of debilitating spine disorder. Recently her group has focused on improving 3D tissue engineered models of bone to create humanised in vitro bone matrices that replicate important feature of bone matrix. Gwen was the president of the European Society for Biomechanics 2014-2016.
Dr Rebecca Gosling- Interim Director of Translation
Dr Rebecca Gosling joined the University of Sheffield in 2012 as an Academic foundation doctor having completed her undergraduate studies in Manchester. She received a BSc in Physiology in 2010 before going onto to obtain her medical degree in 2012. As an academic foundation doctor, she developed her interest in cardiology research particularly in the treatment of acute coronary syndromes and stable angina and imaging in coronary artery disease. She was subsequently awarded an NIHR academic clinical fellowship. During this time, she developed a keen interest in computational modelling and its application to cardiac imaging techniques. She went on to obtain a BHF clinical research training fellowship within the Department of Infection, Immunity and Cardiovascular Disease through which she is studying the application of computational modelling to coronary artery stenting. She is a member of the mathematical modelling in medicine group. She is also an Honorary specialist training registrar in Cardiology at Sheffield Teaching Hospitals NHS Foundation Trust.
Rebecca’s research interests are in computational modelling of coronary physiology and personalised medicine. This involves applying computational fluid dynamics technology to coronary imaging, permitting the computation of physiological parameters such as pressure and flow. Her current work is focused on the development of a virtual stenting model that can predict the physiological outcome to different coronary intervention strategies. This novel approach permits personalised treatment planning by computing the expecting physiological response to stenting strategies.