Multiscale computational biomechanics and simulation in the skeletal system, Sheffield

Multiscale computational biomechanics and simulation in the skeletal system, Sheffield

Professor Ralph Müller will be giving a seminar on ‘Multiscale computational biomechanics and simulation in the skeletal system’ on Thursday June 8th at 2:30 pm in F12-F13 rooms of Pam Liversidge Building.  The seminar will be followed by a Q&A session.

Ralph Müller, PhD
Institute for Biomechanics, ETH Zurich, Zurich, Switzerland
Department of Bioengineering, Imperial College London, London, UK


Bone is one of the most investigated biological materials due to its primary function of providing skeletal stability. Bone is susceptible to different local stimuli including mechanical forces and has great capabilities in adapting its mechanical properties to the changes in its environment. Nevertheless, aging or hormonal changes can make bone lose its ability to remodel appropriately, with loss of strength and increased fracture risk as a result, leading to devastating diseases such as osteoporosis. To better understand the biomechanical function of bone, one has to understand the hierarchical organization of this fascinating material down from the molecules, to the cells, tissue and up to the organ. In this lecture, state-of- the-art imaging and simulation techniques to assess biomechanical function of bone will be presented and how these techniques might be used in a combined experimental and computational approach to further our understanding of the mechanisms governing load induced bone remodeling and its associated biochemical signaling cascades.

Multiscale imaging and simulation allows linking the different levels of hierarchy and to make in silico predictions of micro-architectural changes in bone geometry.

Incorporating systems biology approaches, not only biomechanical strength of the material can be assessed, but also the mechanobiological response of the bone triggered by loading and injury in scenarios relevant for personalized medicine.


Dr. Müller is currently a Professor of Biomechanics at ETH Zurich. His research employs state-of- the-art biomechanical testing and simulation techniques as well as novel bioimaging and visualization strategies for musculoskeletal tissues. His approaches are now often used for precise phenotypic characterization of tissue response in mammalian genetics, mechanobiology as well as tissue engineering and regenerative medicine. A prolific and highly cited author, Dr. Müller has received numerous awards and in 2015 was elected to the Swiss Academy of Engineering Sciences (SATW) and as a Fellow of the European Alliance for Medical and Biological Engineering and Science (EAMBES). In 2017, the European Research Council (ERC) awarded him with a prestigious ERC Advanced Grant (MechAGE) to investigate in vivo single-cell mechanomics of bone adaptation and regeneration in the aging mouse.