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Insigneo Seminar: human in silico clinical trials in cardiology and pharmacology

Wednesday, 19 June, 5:00 pm - 6:00 pm BST

The Insigneo Institute and the Complex Systems Modelling research group are pleased to announce this Summer 2019 Lecture, delivered by Prof Blanca Rodriguez from the University of Oxford.

Human In Silico Clinical Trials in Cardiology and Pharmacology.

Date: Wednesday 19th June
Time: 5-6pm
Location: Lecture Theatre 4 – The Diamond Building

Abstract
In silico clinical trials in medicine refer to the evaluation of a medical therapy using simulations with computer models. Already established in engineering applications (such as aeronautics), in silico trials are now starting to be more widely adopted in medicine with broad potential impact in academy, industry and regulatory bodies. The socio-economic potential in this area is thus huge.

In my talk, I will describe our progress in computational modelling and simulation of human heart towards the realisation of in silico clinical trials for cardiac pharmacology and medicine. I will describe the causes of variability in the response of human hearts to pharmacological therapy, and their importance in assessing safety and efficacy during drug development. I will then address the synergies gained from combining modelling and simulation science with machine learning to unravel the causes of phenotypic variability in disease and drug response, and their implications for the advancement of human in silico trials in medicine. I will emphasize the strong collaborations underpinning this work with key partnerships in industry, regulatory agencies and experimental and clinical biomedicine. Through my talk, I will discuss the importance and challenges of inter-disciplinary, inter-sectoral collaborations in computational medicine.

Biosketch
Blanca Rodriguez is Professor of Computational Medicine, Head of the Computational Biology and Health Informatics Theme and Wellcome Trust Senior Research Fellow at the University of Oxford. She is interested in investigating the causes and modulators of variability in the response of the heart to disease and therapies. With her team, she embeds computational methods in cardiovascular research to augment experimental and clinical investigations (www.cs.ox.ac.uk/ccs). Their research is supported by an established network of collaborators in academia and industry, who are world-leading experts in in vivo and in vitro human cardiovascular medicine and pharmacology.

Blanca has been in Oxford since 2004. Before her current post, she held Medical Research Council Career Development and Centenary Awards at Oxford (2007-2013) and worked in the USA as a postdoctoral research fellow at Tulane University in New Orleans (2002-2004). She is an Electronics Engineer by training from the Universidad Politecnica de Valencia, where she also conducted her PhD in Bioelectronics (1998-2001).

Tickets are available via Eventbrite at the link below:
https://www.eventbrite.com/e/human-in-silico-clinical-trials-in-cardiology-and-pharmacology-tickets-59881609506

The Complex Systems Modelling Summer Lecture is a public lecture organised by the Complex Systems Modelling Group, in the Department of Computer Science https://www.sheffield.ac.uk/dcs/research/groups/complex-systems-modelling

Venue

Lecture Theatre 4 – The Diamond Building
32 Leavygreave Rd
Sheffield, S3 7RD
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Organiser

The Complex Systems Modelling research group
Website:
https://www.sheffield.ac.uk/dcs/research/groups/complex-systems-modelling