Prenatal growth map of the mouse knee joint by means of deformable registration technique

Prenatal growth map of the mouse knee joint by means of deformable registration technique

Researchers from our MultiSim project have published a paper in the journal PLoS One on ‘Prenatal growth map of the mouse knee joint by means of deformable registration technique’.

Joint morphogenesis is the process of development of the joint that starts before the birth.

It is important to study joint morphogenesis in order to understand how it is related to musculoskeletal diseases and to optimise related interventions. In several cases the interventions are tested on animal models and the mouse pre-natal model is typically used to test the effect of diseases and treatments on the joints.

In this study, we developed a procedure that combines Optical Projection Tomography imaging (OPT) and a deformable registration algorithm to obtain realistic 3D realistic high-resolution developmental map of the prenatal mouse knee joint. We have found that the developed procedure has acceptable uncertainties of the displacement measurements and that it is well reproducible.

This approach will be used to study how growth and adaptation are directed by biological and mechanobiological factors.

Publication:

Giorgi, M., Sotirou, V., Franchini, N., Conigliaro, S., Biganardi, C., Nowlan, N. C., Dall’Ara, E., (2019), “Prenatal growth map of the mouse knee joint by means of deformable registration technique”, PLoS One, 14 (1): e0197947, URL: https://doi.org/10.1371/journal.pone.0197947