Dr Grogan from the University of Oxford is visiting Insigneo this week and will be giving a seminar on Friday 12 May from 12:30 to 13.30 in the Pam Liversidge building (Room F12-F13). A light lunch will be provided.
Spatial Modelling of Vascularized Tissues using Microvessel Chaste
Spatial models of vascularized tissues are widely used in computational physiology, to study for example, tumour growth, angiogenesis, osteogenesis, coronary perfusion and oxygen delivery. Composition of such models is time-consuming, with many researchers writing custom software for this purpose. Microvessel Chaste is a new open-source Python/C++ library for building spatial models of vascularized tissue growth. It can be used to simulate vessel growth and adaptation in response to mechanical and chemical stimuli, intra- and extra-vascular transport of nutrient, growth factor and drugs, and cell proliferation in complex 3D geometries.
Here, two example applications of the library are presented. The first is a study into the effect of microvessel structure on the response of tumours to radiotherapy. High resolution, three dimensional images of tumour microvessel networks are obtained using multiphoton imaging in mouse. The images are segmented and the resulting vessel network geometries are used to simulate tumour growth and radiotherapy response. The second is a study of angiogenesis in the corneal micropocket assay. This assay is widely used to screen candidate anti-angiogenic therapies in cancer and involves placing a pellet containing pro- and anti-angiogenic factors into the cornea of a mouse. Here we study vessel network formation in the assay using a detailed, agent-based model of angiogenesis and a three-dimensional anatomical representation of the mouse cornea. For further information see the Microvessel Chaste website: https://jmsgrogan.github.io/MicrovesselChaste.